Munc13-4*rab27 complex tethers secretory lysosomes at the plasma membrane

Natural Killer (NK) cells and Cytotoxic T lymphocytes (CTL) are critical for the immune response against virus infections or transformed cells. They kill target cells via polarized exocytosis of lytic proteins from secretory lysosomes (SL). Rab27a and munc13-4 interact directly and are required for...

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Autori principali: Elstak, Edo D., Neeft, Maaike, Nehme, Nadine T., Callebaut, Isabelle, de Saint Basile, Geneviève, van der Sluijs, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291317/
https://ncbi.nlm.nih.gov/pubmed/22482013
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