Munc13-4 Is an Effector of Rab27a and Controls Secretion of Lysosomes in Hematopoietic Cells

Griscelli syndrome type 2 (GS2) is a genetic disorder in which patients exhibit life-threatening defects of cytotoxic T lymphocytes (CTLs) whose lytic granules fail to dock on the plasma membrane and therefore do not release their contents. The disease is caused by the absence of functional rab27a,...

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Autors principals: Neeft, Maaike, Wieffer, Marnix, de Jong, Arjan S., Negroiu, Gabriela, Metz, Corina H.G., van Loon, Alexander, Griffith, Janice, Krijgsveld, Jeroen, Wulffraat, Nico, Koch, Henriette, Heck, Albert J.R., Brose, Nils, Kleijmeer, Monique, van der Sluijs, Peter
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2005
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC545907/
https://ncbi.nlm.nih.gov/pubmed/15548590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-10-0923
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