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Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukemia

Tissue stromal cells interact with leukemia cells and profoundly affect their viability and drug sensitivity. Here we show a biochemical mechanism by which bone marrow stromal cells modulate the redox status of chronic lymphocytic leukemia (CLL) cells and promote cellular survival and drug resistanc...

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Detalhes bibliográficos
Main Authors: Zhang, Wan, Trachootham, Dunyaporn, Liu, Jinyun, Chen, Gang, Pelicano, Helene, Garcia-Prieto, Celia, Lu, Weiqin, Burger, Jan A, Croce, Carlo M, Plunkett, William, Keating, Michael J, Huang, Peng
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290742/
https://ncbi.nlm.nih.gov/pubmed/22344033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2432
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