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Abnormal MDMX degradation in tumor cells due to ARF deficiency
MDMX is a hetero dimeric partner of MDM2 and a critical regulator of p53. MDMX level is generally elevated in tumors with wild type p53 and contributes to p53 inactivation. MDMX degradation is controlled in part by MDM2-mediated ubiquitination. Here we show that MDMX turnover is highly responsive to...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290737/ https://ncbi.nlm.nih.gov/pubmed/22120712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.534 |
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