Abnormal MDMX degradation in tumor cells due to ARF deficiency

MDMX is a hetero dimeric partner of MDM2 and a critical regulator of p53. MDMX level is generally elevated in tumors with wild type p53 and contributes to p53 inactivation. MDMX degradation is controlled in part by MDM2-mediated ubiquitination. Here we show that MDMX turnover is highly responsive to...

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Autori principali: Li, Xiaolong, Gilkes, Daniele, Li, Baozong, Cheng, Qian, Pernazza, Daniele, Lawrence, Nicholas, Chen, Jiandong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290737/
https://ncbi.nlm.nih.gov/pubmed/22120712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.534
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