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mtDNA lineage analysis of mouse L-cell lines reveals the accumulation of multiple mtDNA mutants and intermolecular recombination

The role of mitochondrial DNA (mtDNA) mutations and mtDNA recombination in cancer cell proliferation and developmental biology remains controversial. While analyzing the mtDNAs of several mouse L cell lines, we discovered that every cell line harbored multiple mtDNA mutants. These included four miss...

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Main Authors: Fan, Weiwei, Lin, Chun Shi, Potluri, Prasanth, Procaccio, Vincent, Wallace, Douglas C.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289886/
https://ncbi.nlm.nih.gov/pubmed/22345519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.175802.111
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