Mouse mtDNA mutant model of Leber hereditary optic neuropathy

An animal model of Leber hereditary optic neuropathy (LHON) was produced by introducing the human optic atrophy mtDNA ND6 P25L mutation into the mouse. Mice with this mutation exhibited reduction in retinal function by elecroretinogram (ERG), age-related decline in central smaller caliber optic nerv...

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Bibliografiset tiedot
Päätekijät: Lin, Chun Shi, Sharpley, Mark S., Fan, Weiwei, Waymire, Katrina G., Sadun, Alfredo A., Carelli, Valerio, Ross-Cisneros, Fred N., Baciu, Peter, Sung, Eric, McManus, Meagan J., Pan, Billy X., Gil, Daniel W., MacGregor, Grant R., Wallace, Douglas C.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2012
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523873/
https://ncbi.nlm.nih.gov/pubmed/23129651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217113109
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