Mouse mtDNA mutant model of Leber hereditary optic neuropathy

An animal model of Leber hereditary optic neuropathy (LHON) was produced by introducing the human optic atrophy mtDNA ND6 P25L mutation into the mouse. Mice with this mutation exhibited reduction in retinal function by elecroretinogram (ERG), age-related decline in central smaller caliber optic nerv...

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書誌詳細
主要な著者: Lin, Chun Shi, Sharpley, Mark S., Fan, Weiwei, Waymire, Katrina G., Sadun, Alfredo A., Carelli, Valerio, Ross-Cisneros, Fred N., Baciu, Peter, Sung, Eric, McManus, Meagan J., Pan, Billy X., Gil, Daniel W., MacGregor, Grant R., Wallace, Douglas C.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2012
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523873/
https://ncbi.nlm.nih.gov/pubmed/23129651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217113109
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