Mouse mtDNA mutant model of Leber hereditary optic neuropathy

An animal model of Leber hereditary optic neuropathy (LHON) was produced by introducing the human optic atrophy mtDNA ND6 P25L mutation into the mouse. Mice with this mutation exhibited reduction in retinal function by elecroretinogram (ERG), age-related decline in central smaller caliber optic nerv...

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Bibliografiske detaljer
Main Authors: Lin, Chun Shi, Sharpley, Mark S., Fan, Weiwei, Waymire, Katrina G., Sadun, Alfredo A., Carelli, Valerio, Ross-Cisneros, Fred N., Baciu, Peter, Sung, Eric, McManus, Meagan J., Pan, Billy X., Gil, Daniel W., MacGregor, Grant R., Wallace, Douglas C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523873/
https://ncbi.nlm.nih.gov/pubmed/23129651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217113109
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