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Mouse mtDNA mutant model of Leber hereditary optic neuropathy
An animal model of Leber hereditary optic neuropathy (LHON) was produced by introducing the human optic atrophy mtDNA ND6 P25L mutation into the mouse. Mice with this mutation exhibited reduction in retinal function by elecroretinogram (ERG), age-related decline in central smaller caliber optic nerv...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3523873/ https://ncbi.nlm.nih.gov/pubmed/23129651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1217113109 |
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