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mtDNA lineage analysis of mouse L-cell lines reveals the accumulation of multiple mtDNA mutants and intermolecular recombination

The role of mitochondrial DNA (mtDNA) mutations and mtDNA recombination in cancer cell proliferation and developmental biology remains controversial. While analyzing the mtDNAs of several mouse L cell lines, we discovered that every cell line harbored multiple mtDNA mutants. These included four miss...

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Detalhes bibliográficos
Main Authors: Fan, Weiwei, Lin, Chun Shi, Potluri, Prasanth, Procaccio, Vincent, Wallace, Douglas C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289886/
https://ncbi.nlm.nih.gov/pubmed/22345519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.175802.111
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