A Live-attenuated Listeria Vaccine (ANZ-100) and a Live-attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase 1 Studies of Safety and Immune Induction

PURPOSE: Listeria monocytogenes (Lm)-based vaccines stimulate both innate and adaptive immunity. ANZ-100 is a live-attenuated Lm strain (Lm ΔactA/ΔinlB). Uptake by phagocytes in the liver results in local inflammatory responses, and activation and recruitment of NK and T cells, in association with i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Le, Dung T., Brockstedt, Dirk G., Nir-Paz, Ran, Hampl, Johannes, Mathur, Shruti, Nemunaitis, John, Sterman, Daniel H., Hassan, Raffit, Lutz, Eric, Moyer, Bentley, Giedlin, Martin, Louis, Jana-Lynn, Sugar, Elizabeth A., Pons, Alice, Cox, Andrea L., Levine, Jordana, Murphy, Aimee Luck, Illei, Peter, Dubensky, Thomas W., Eiden, Joseph E., Jaffee, Elizabeth M., Laheru, Daniel A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2011
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289408/
https://ncbi.nlm.nih.gov/pubmed/22147941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2121
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