Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

PURPOSE: GVAX pancreas, granulocyte-macrophage colony-stimulating factor–secreting allogeneic pancreatic tumor cells, induces T-cell immunity to cancer antigens, including mesothelin. GVAX is administered with low-dose cyclophosphamide (Cy) to inhibit regulatory T cells. CRS-207, live-attenuated Lis...

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發表在:J Clin Oncol
Main Authors: Le, Dung T., Wang-Gillam, Andrea, Picozzi, Vincent, Greten, Tim F., Crocenzi, Todd, Springett, Gregory, Morse, Michael, Zeh, Herbert, Cohen, Deirdre, Fine, Robert L., Onners, Beth, Uram, Jennifer N., Laheru, Daniel A., Lutz, Eric R., Solt, Sara, Murphy, Aimee Luck, Skoble, Justin, Lemmens, Ed, Grous, John, Dubensky, Thomas, Brockstedt, Dirk G., Jaffee, Elizabeth M.
格式: Artigo
語言:Inglês
出版: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397277/
https://ncbi.nlm.nih.gov/pubmed/25584002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.57.4244
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