Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

PURPOSE: GVAX pancreas, granulocyte-macrophage colony-stimulating factor–secreting allogeneic pancreatic tumor cells, induces T-cell immunity to cancer antigens, including mesothelin. GVAX is administered with low-dose cyclophosphamide (Cy) to inhibit regulatory T cells. CRS-207, live-attenuated Lis...

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Dettagli Bibliografici
Pubblicato in:J Clin Oncol
Autori principali: Le, Dung T., Wang-Gillam, Andrea, Picozzi, Vincent, Greten, Tim F., Crocenzi, Todd, Springett, Gregory, Morse, Michael, Zeh, Herbert, Cohen, Deirdre, Fine, Robert L., Onners, Beth, Uram, Jennifer N., Laheru, Daniel A., Lutz, Eric R., Solt, Sara, Murphy, Aimee Luck, Skoble, Justin, Lemmens, Ed, Grous, John, Dubensky, Thomas, Brockstedt, Dirk G., Jaffee, Elizabeth M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397277/
https://ncbi.nlm.nih.gov/pubmed/25584002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.57.4244
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