Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

PURPOSE: GVAX pancreas, granulocyte-macrophage colony-stimulating factor–secreting allogeneic pancreatic tumor cells, induces T-cell immunity to cancer antigens, including mesothelin. GVAX is administered with low-dose cyclophosphamide (Cy) to inhibit regulatory T cells. CRS-207, live-attenuated Lis...

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Detalhes bibliográficos
Publicado no:J Clin Oncol
Main Authors: Le, Dung T., Wang-Gillam, Andrea, Picozzi, Vincent, Greten, Tim F., Crocenzi, Todd, Springett, Gregory, Morse, Michael, Zeh, Herbert, Cohen, Deirdre, Fine, Robert L., Onners, Beth, Uram, Jennifer N., Laheru, Daniel A., Lutz, Eric R., Solt, Sara, Murphy, Aimee Luck, Skoble, Justin, Lemmens, Ed, Grous, John, Dubensky, Thomas, Brockstedt, Dirk G., Jaffee, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4397277/
https://ncbi.nlm.nih.gov/pubmed/25584002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.57.4244
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