A Pilot Study of IL-2Rα Blockade during Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with Glioblastoma

BACKGROUND: Preclinical studies in mice have demonstrated that the prophylactic depletion of immunosuppressive regulatory T-cells (T(Regs)) through targeting the high affinity interleukin-2 (IL-2) receptor (IL-2Rα/CD25) can enhance anti-tumor immunotherapy. However, therapeutic approaches are compli...

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Autori principali: Sampson, John H., Schmittling, Robert J., Archer, Gary E., Congdon, Kendra L., Nair, Smita K., Reap, Elizabeth A., Desjardins, Annick, Friedman, Allan H., Friedman, Henry S., Herndon, James E., Coan, April, McLendon, Roger E., Reardon, David A., Vredenburgh, James J., Bigner, Darell D., Mitchell, Duane A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288003/
https://ncbi.nlm.nih.gov/pubmed/22383993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031046
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