Greater chemotherapy-induced lymphopenia enhances tumor-specific immune responses that eliminate EGFRvIII-expressing tumor cells in patients with glioblastoma

Epidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation widely expressed in glioblastoma multiforme (GBM) and other neoplasms, but absent from normal tissues. Immunotherapeutic targeting of EGFRvIII could eliminate neoplastic cells more precisely but may be inhibited by...

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Detalhes bibliográficos
Main Authors: Sampson, John H., Aldape, Kenneth D., Archer, Gary E., Coan, April, Desjardins, Annick, Friedman, Allan H., Friedman, Henry S., Gilbert, Mark R., Herndon, James E., McLendon, Roger E., Mitchell, Duane A., Reardon, David A., Sawaya, Raymond, Schmittling, Robert, Shi, Weiming, Vredenburgh, James J., Bigner, Darell D., Heimberger, Amy B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064599/
https://ncbi.nlm.nih.gov/pubmed/21149254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq157
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