Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humans

Lymphodepletion augments adoptive cell transfer during antitumor immunotherapy, producing dramatic clinical responses in patients with malignant melanoma. We report that the lymphopenia induced by the chemotherapeutic agent temozolomide (TMZ) enhances vaccine-driven immune responses and significantl...

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Detalhes bibliográficos
Main Authors: Mitchell, Duane A., Cui, Xiuyu, Schmittling, Robert J., Sanchez-Perez, Luis, Snyder, David J., Congdon, Kendra L., Archer, Gary E., Desjardins, Annick, Friedman, Allan H., Friedman, Henry S., Herndon, James E., McLendon, Roger E., Reardon, David A., Vredenburgh, James J., Bigner, Darell D., Sampson, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3175779/
https://ncbi.nlm.nih.gov/pubmed/21768296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-334565
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