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The role of conserved water molecules in the catalytic domain of protein kinases

Protein kinases are essential signaling molecules with a characteristic bilobal shape that has been studied for over fifteen years. Despite the number of crystal structures available, little study has been directed away from the prototypical functional elements of the kinase domain. We have performe...

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Autors principals: Knight, James D. R., Hamelberg, Donald, McCammon, J. Andrew, Kothary, Rashmi
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287957/
https://ncbi.nlm.nih.gov/pubmed/19425109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22451
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