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Mechanistic Insight into the Role of Transition-State Stabilization in Cyclophilin A

[Image: see text] Peptidyl prolyl cis−trans isomerases (PPIases) are ubiquitous enzymes in biology that catalyze the cis−trans isomerization of the proline imide peptide bond in many cell signaling pathways. The local change of the isomeric state of the prolyl peptide bond acts as a switching mechan...

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Detalhes bibliográficos
Main Authors: Hamelberg, Donald, McCammon, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2008
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651649/
https://ncbi.nlm.nih.gov/pubmed/19128175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja806146g
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