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The role of conserved water molecules in the catalytic domain of protein kinases

Protein kinases are essential signaling molecules with a characteristic bilobal shape that has been studied for over fifteen years. Despite the number of crystal structures available, little study has been directed away from the prototypical functional elements of the kinase domain. We have performe...

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Detalhes bibliográficos
Main Authors: Knight, James D. R., Hamelberg, Donald, McCammon, J. Andrew, Kothary, Rashmi
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3287957/
https://ncbi.nlm.nih.gov/pubmed/19425109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22451
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