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Release of ADP from the catalytic subunit of protein kinase A: A molecular dynamics simulation study
Substrate phosphorylation by cAMP-dependent-protein kinase A (protein kinase A, PKA) has been studied extensively. Phosphoryl transfer was found to be fast, whereas ADP release was found to be the slow, rate-limiting step. There is also evidence that ADP release may be preceded by a partially rate-l...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253316/ https://ncbi.nlm.nih.gov/pubmed/15608120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04894605 |
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