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MM-PBSA Captures Key Role of Intercalating Water Molecules at a Protein−Protein Interface

The calculation of protein interaction energetics is of fundamental interest, yet accurate quantities are difficult to obtain due to the complex and dynamic nature of protein interfaces. This is further complicated by the presence of water molecules, which can exhibit transient interactions of varia...

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Bibliographische Detailangaben
Hauptverfasser: Wong, Sergio, Amaro, Rommie E., McCammon, J. Andrew
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2009
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651627/
https://ncbi.nlm.nih.gov/pubmed/19461869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct8003707
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