Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Glioblastoma, the most common primary malignant cancer of the brain, is characterized by rapid tumor growth and infiltration of tumor cells throughout the brain. These traits cause glioblastomas to be highly resistant to current therapies with a resultant poor prognosis. Although aberrant oncogenic...

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Autors principals: Feng, Haizhong, Hu, Bo, Jarzynka, Michael J., Li, Yanxin, Keezer, Susan, Johns, Terrance G., Tang, Careen K., Hamilton, Ronald L., Vuori, Kristiina, Nishikawa, Ryo, Sarkaria, Jann N., Fenton, Tim, Cheng, Tao, Furnari, Frank B., Cavenee, Webster K., Cheng, Shi-Yuan
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3286964/
https://ncbi.nlm.nih.gov/pubmed/22323579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121457109
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