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CXCR4 Suppression Attenuates EGFRvIII-Mediated Invasion and Induces p38 MAPK-Dependent Protein Trafficking and Degradation of EGFRvIII in Breast Cancer Cells
Our previous report has shown that the constitutively activated EGFR variant, EGFRvIII, up-regulates the pro-metastatic chemokine receptor CXCR4 in breast cancer cells. Here we evaluated the biological effect and cell signaling effects of silencing CXCR4 expression in EGFRvIII-expressing breast canc...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100082/ https://ncbi.nlm.nih.gov/pubmed/21454012 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.02.024 |
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