Up-regulation of Cavβ(3) Subunit in Primary Sensory Neurons Increases Voltage-activated Ca(2+) Channel Activity and Nociceptive Input in Neuropathic Pain

High voltage-activated calcium channels (HVACCs) are essential for synaptic and nociceptive transmission. Although blocking HVACCs can effectively reduce pain, this treatment strategy is associated with intolerable adverse effects. Neuronal HVACCs are typically composed of α(1), β (Cavβ), and α(2)δ...

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Detalhes bibliográficos
Main Authors: Li(李, Li, 莉), Cao(红, Xue-Hong, 曹雪), Chen(瑞, Shao-Rui, 陈少), Han(동, Hee-Dong, 한희), Lopez-Berestein, Gabriel, Sood, Anil K., Pan(麟, Hui-Lin, 潘惠)
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285367/
https://ncbi.nlm.nih.gov/pubmed/22187436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310110
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