Up-regulation of Cavβ(3) Subunit in Primary Sensory Neurons Increases Voltage-activated Ca(2+) Channel Activity and Nociceptive Input in Neuropathic Pain

High voltage-activated calcium channels (HVACCs) are essential for synaptic and nociceptive transmission. Although blocking HVACCs can effectively reduce pain, this treatment strategy is associated with intolerable adverse effects. Neuronal HVACCs are typically composed of α(1), β (Cavβ), and α(2)δ...

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Hlavní autoři: Li(李, Li, 莉), Cao(红, Xue-Hong, 曹雪), Chen(瑞, Shao-Rui, 陈少), Han(동, Hee-Dong, 한희), Lopez-Berestein, Gabriel, Sood, Anil K., Pan(麟, Hui-Lin, 潘惠)
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285367/
https://ncbi.nlm.nih.gov/pubmed/22187436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310110
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