Chronic Opioid Potentiates Presynaptic but Impairs Postsynaptic N-Methyl-d-aspartic Acid Receptor Activity in Spinal Cords: IMPLICATIONS FOR OPIOID HYPERALGESIA AND TOLERANCE

Opioids are the most effective analgesics for the treatment of moderate to severe pain. However, chronic opioid treatment can cause both hyperalgesia and analgesic tolerance, which limit their clinical efficacy. In this study, we determined the role of pre- and postsynaptic NMDA receptors (NMDARs) i...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhao(赵, Yi-Lin, 以林), Chen(陈, Shao-Rui, 少瑞), Chen(陈, Hong, 红), Pan(潘, Hui-Lin, 惠麟)
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Neurobiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408179/
https://ncbi.nlm.nih.gov/pubmed/22679016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.378737
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