Chronic Opioid Potentiates Presynaptic but Impairs Postsynaptic N-Methyl-d-aspartic Acid Receptor Activity in Spinal Cords: IMPLICATIONS FOR OPIOID HYPERALGESIA AND TOLERANCE

Opioids are the most effective analgesics for the treatment of moderate to severe pain. However, chronic opioid treatment can cause both hyperalgesia and analgesic tolerance, which limit their clinical efficacy. In this study, we determined the role of pre- and postsynaptic NMDA receptors (NMDARs) i...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhao(赵, Yi-Lin, 以林), Chen(陈, Shao-Rui, 少瑞), Chen(陈, Hong, 红), Pan(潘, Hui-Lin, 惠麟)
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2012
Konular:
Neurobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3408179/
https://ncbi.nlm.nih.gov/pubmed/22679016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.378737
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