N-Methyl-d-aspartate Receptor- and Calpain-mediated Proteolytic Cleavage of K(+)-Cl(−) Cotransporter-2 Impairs Spinal Chloride Homeostasis in Neuropathic Pain

Loss of synaptic inhibition by γ-aminobutyric acid and glycine due to potassium chloride cotransporter-2 (KCC2) down-regulation in the spinal cord is a critical mechanism of synaptic plasticity in neuropathic pain. Here we present novel evidence that peripheral nerve injury diminishes glycine-mediat...

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Main Authors: Zhou(周, Hong-Yi, 红义), Chen(陈, Shao-Rui, 少瑞), Byun(변, Hee-Sun, 희선), Chen(陈, Hong, 红), Li(李, Li, 莉), Han(한, Hee-Dong, 희동), Lopez-Berestein, Gabriel, Sood, Anil K., Pan(潘, Hui-Lin, 惠麟)
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3460480/
https://ncbi.nlm.nih.gov/pubmed/22854961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.395830
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