Contribution of Phosphates and Adenine to the Potency of Adenophostins at the IP(3) Receptor: Synthesis of All Possible Bisphosphates of Adenophostin A

[Image: see text] Although adenophostin A (AdA), the most potent agonist of d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)R), is thought to mimic IP(3), the relative roles of the different phosphate groups and the adenosine motif have not been established. We synthesized all three possible bisp...

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Main Authors: Sureshan, Kana M., Riley, Andrew M., Thomas, Mark P., Tovey, Stephen C., Taylor, Colin W., Potter, Barry V. L.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2012
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285137/
https://ncbi.nlm.nih.gov/pubmed/22248345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm201571p
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