Binding of Inositol 1,4,5-trisphosphate (IP(3)) and Adenophostin A to the N-Terminal region of the IP(3) Receptor: Thermodynamic Analysis Using Fluorescence Polarization with a Novel IP(3) Receptor Ligand

Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)R) are intracellular Ca(2+) channels. Their opening is initiated by binding of IP(3) to the IP(3)-binding core (IBC; residues 224–604 of IP(3)R1) and transmitted to the pore via the suppressor domain (SD; residues 1–223). The major conformational...

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Main Authors: Ding, Zhao, Rossi, Ana M., Riley, Andrew M., Rahman, Taufiq, Potter, Barry V. L., Taylor, Colin W.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2879921/
https://ncbi.nlm.nih.gov/pubmed/20215561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.062596
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