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Binding of Inositol 1,4,5-trisphosphate (IP(3)) and Adenophostin A to the N-Terminal region of the IP(3) Receptor: Thermodynamic Analysis Using Fluorescence Polarization with a Novel IP(3) Receptor Ligand
Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)R) are intracellular Ca(2+) channels. Their opening is initiated by binding of IP(3) to the IP(3)-binding core (IBC; residues 224–604 of IP(3)R1) and transmitted to the pore via the suppressor domain (SD; residues 1–223). The major conformational...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Pharmacology and Experimental
Therapeutics
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2879921/ https://ncbi.nlm.nih.gov/pubmed/20215561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.062596 |
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