Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors

[Image: see text] d-myo-Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are Ca(2+) channels activated by the intracellular messenger inositol 1,4,5-trisphosphate (IP(3), 1). The glyconucleotide adenophostin A (AdA, 2) is a potent agonist of IP(3)Rs. A recent synthesis of d-chiro-inositol adenophost...

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Udgivet i:ACS Omega
Main Authors: Su, Xiangdong, Dohle, Wolfgang, Mills, Stephen J., Watt, Joanna M., Rossi, Ana M., Taylor, Colin W., Potter, Barry V. L.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659177/
https://ncbi.nlm.nih.gov/pubmed/33195933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c04145
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