Activation of IP(3) receptors by synthetic bisphosphate ligands

Ca(2+) release by d-myo-inositol 1,4,5-trisphosphate receptors (IP(3)Rs) is widely considered to require the vicinal 4,5-bisphosphate motif of IP(3), with P-5 and P-4 engaging the α and β domains of the binding site; using synthesis and mutagenesis we show that the adenine of synthetic glyconucleoti...

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Main Authors: Sureshan, Kana M., Riley, Andrew M., Rossi, Ana M., Tovey, Stephen C., Dedos, Skarlatos G., Taylor, Colin W., Potter, Barry V. L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Royal Society of Chemistry 2009
Ábhair:
Chemistry
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898634/
https://ncbi.nlm.nih.gov/pubmed/19240874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b819328b
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