Synthetic partial agonists reveal key steps in IP(3) receptor activation

Inositol 1,4,5-trisphosphate receptors (IP(3)R) are ubiquitous intracellular Ca(2+) channels. IP(3)binding to the IP(3)-binding core (IBC) near the N-terminal initiates conformational changes that lead to opening of a pore. The mechanisms are unresolved. We synthesized 2-O-modified IP(3) analogues t...

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Main Authors: Rossi, Ana M., Riley, Andrew M., Tovey, Stephen C., Taufiq-Ur-Rahman, Dellis, Olivier, Taylor, Emily J. A., Veresov, Valery G., Potter, Barry V. L., Taylor, Colin W.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2869033/
https://ncbi.nlm.nih.gov/pubmed/19668195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.195
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