Replication Bypass of the trans-4-Hydroxynonenal-Derived (6S,8R,11S)-1,N(2)-Deoxyguanosine DNA Adduct by the Sulfolobus solfataricus DNA Polymerase IV

[Image: see text] trans-4-Hydroxynonenal (HNE) is the major peroxidation product of ω-6 polyunsaturated fatty acids in vivo. Michael addition of the N(2)-amino group of dGuo to HNE followed by ring closure of N1 onto the aldehyde results in four diastereomeric 1,N(2)-dGuo (1,N(2)-HNE-dGuo) adducts....

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Bibliographic Details
Main Authors: Banerjee, Surajit, Christov, Plamen P., Kozekova, Albena, Rizzo, Carmelo J., Egli, Martin, Stone, Michael P.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2012
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3285121/
https://ncbi.nlm.nih.gov/pubmed/22313351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200460j
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