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Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice
Alkaline sphingomyelinase (alk-SMase) hydrolyses sphingomyelin (SM) to ceramide in the gut. To evaluate the physiological importance of the enzyme, we generated alk-SMase knockout (KO) mice by the Cre-recombinase-Locus of X-over P1(Cre-LoxP) system and studied SM digestion. Both wild-type (WT) and K...
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| Auteurs principaux: | , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Biochemistry and Molecular Biology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3284167/ https://ncbi.nlm.nih.gov/pubmed/21177474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M012880 |
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