Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice

Alkaline sphingomyelinase (alk-SMase) hydrolyses sphingomyelin (SM) to ceramide in the gut. To evaluate the physiological importance of the enzyme, we generated alk-SMase knockout (KO) mice by the Cre-recombinase-Locus of X-over P1(Cre-LoxP) system and studied SM digestion. Both wild-type (WT) and K...

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Bibliographic Details
Main Authors: Zhang, Yao, Cheng, Yajun, Hansen, Gert H., Niels-Christiansen, Lise-Lotte, Koentgen, Frank, Ohlsson, Lena, Nilsson, Åke, Duan, Rui-Dong
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2011
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3284167/
https://ncbi.nlm.nih.gov/pubmed/21177474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M012880
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