Dual Beneficial Effect of Interloop Disulfide Bond for Single Domain Antibody Fragments

The antigen-binding fragment of functional heavy chain antibodies (HCAbs) in camelids comprises a single domain, named the variable domain of heavy chain of HCAbs (VHH). The VHH harbors remarkable amino acid substitutions in the framework region-2 to generate an antigen-binding domain that functions...

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Main Authors: Govaert, Jochen, Pellis, Mireille, Deschacht, Nick, Vincke, Cécile, Conrath, Katja, Muyldermans, Serge, Saerens, Dirk
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Protein Structure and Folding
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283254/
https://ncbi.nlm.nih.gov/pubmed/22128183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.242818
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