Dual Beneficial Effect of Interloop Disulfide Bond for Single Domain Antibody Fragments

The antigen-binding fragment of functional heavy chain antibodies (HCAbs) in camelids comprises a single domain, named the variable domain of heavy chain of HCAbs (VHH). The VHH harbors remarkable amino acid substitutions in the framework region-2 to generate an antigen-binding domain that functions...

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Detalhes bibliográficos
Principais autores: Govaert, Jochen, Pellis, Mireille, Deschacht, Nick, Vincke, Cécile, Conrath, Katja, Muyldermans, Serge, Saerens, Dirk
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283254/
https://ncbi.nlm.nih.gov/pubmed/22128183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.242818
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