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Engineering antibody fragments to fold in the absence of disulfide bonds
Disulfide bonds play a critical role in the stabilization of the immunoglobulin β-sandwich sandwich. Under reducing conditions, such as those that prevail in the cytoplasm, disulfide bonds do not normally form and as a result most antibodies expressed in that compartment (intrabodies) accumulate in...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708069/ https://ncbi.nlm.nih.gov/pubmed/19177559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.31 |
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