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Comprehensive elucidation of the structural and functional roles of engineered disulfide bonds in antibody Fc fragment
Therapeutic monoclonal antibodies and Fc-fusion proteins containing antibody Fc fragment may tend to destabilize (e.g. unfold and aggregate), which leads to loss of functions and increase of adverse risks. Although engineering of an additional disulfide bond has been performed in Fc or Fc domains fo...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6295723/ https://ncbi.nlm.nih.gov/pubmed/30327432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005367 |
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