Wird geladen...

Cataract-Linked γD-Crystallin Mutants Have Weak Affinity to Lens Chaperones α-Crystallins

To test the hypothesis that α-crystallin chaperone activity plays a central role in maintenance of lens transparency, we investigated its interactions with γ-crystallin mutants that cause congenital cataract in mouse models. Although the two substitutions, I4F and V76D, stabilize a partially unfolde...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Mishra, Sanjay, Stein, Richard A., Mchaourab, Hassane S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282170/
https://ncbi.nlm.nih.gov/pubmed/22289178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.01.019
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!