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Cataract-Linked γD-Crystallin Mutants Have Weak Affinity to Lens Chaperones α-Crystallins
To test the hypothesis that α-crystallin chaperone activity plays a central role in maintenance of lens transparency, we investigated its interactions with γ-crystallin mutants that cause congenital cataract in mouse models. Although the two substitutions, I4F and V76D, stabilize a partially unfolde...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3282170/ https://ncbi.nlm.nih.gov/pubmed/22289178 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.01.019 |
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