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Cataract-causing αAG98R-crystallin mutant dissociates into monomers having chaperone activity

PURPOSE: The G98R mutation in αA-crystallin is associated with autosomal dominant cataract in humans. We have reported that mutant G98R protein has substrate-dependent chaperone activity. Further studies on this G98R mutant protein revealed that mutant protein shows reduced oligomeric stability and...

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Detalhes bibliográficos
Main Authors: Raju, Murugesan, Santhoshkumar, Puttur, Sharma, K. Krishna
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3017799/
https://ncbi.nlm.nih.gov/pubmed/21224997
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