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Transgenic zebrafish models reveal distinct molecular mechanisms for cataract-linked αA-crystallin mutants

Mutations in the small heat shock proteins α-crystallins have been linked to autosomal dominant cataracts in humans. Extensive studies in vitro have revealed a spectrum of alterations to the structure and function of these proteins including shifts in the size of the oligomer, modulation of subunit...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Wu, Shu-Yu, Zou, Ping, Mishra, Sanjay, Mchaourab, Hassane S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6261105/
https://ncbi.nlm.nih.gov/pubmed/30475834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207540
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