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Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart
Genetic mutations in the human small heat shock protein αB-crystallin have been implicated in autosomal cataracts and skeletal myopathies, including heart muscle diseases (cardiomyopathy). Although these mutations lead to modulation of their chaperone activity in vitro, the in vivo functions of αB-c...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5767876/ https://ncbi.nlm.nih.gov/pubmed/29162721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808634 |
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