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Cataract-Linked γD-Crystallin Mutants Have Weak Affinity to Lens Chaperones α-Crystallins

To test the hypothesis that α-crystallin chaperone activity plays a central role in maintenance of lens transparency, we investigated its interactions with γ-crystallin mutants that cause congenital cataract in mouse models. Although the two substitutions, I4F and V76D, stabilize a partially unfolde...

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Bibliografische gegevens
Hoofdauteurs: Mishra, Sanjay, Stein, Richard A., Mchaourab, Hassane S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282170/
https://ncbi.nlm.nih.gov/pubmed/22289178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.01.019
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