Polycomb Repressive Complex 2 Regulates Normal Development of the Mouse Heart

RATIONALE: Epigenetic marks are crucial for organogenesis, but their role in heart development is poorly understood. Polycomb Repressive Complex 2 (PRC2) trimethylates histone H3 at lysine 27, establishing H3K27me3 repressive epigenetic marks that promote tissue-specific differentiation by silencing...

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Autores principales: He, Aibin, Ma, Qing, Cao, Jingjing, von Gise, Alexander, Zhou, Pingzhu, Xie, Huafeng, Zhang, Bing, Hsing, Michael, Christodoulou, Danos, Cahan, Patrick, Daley, George Q., Kong, Sek Won, Orkin, Stuart H., Seidman, Christine E., Seidman, J. G., Pu, William T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282145/
https://ncbi.nlm.nih.gov/pubmed/22158708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.252205
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