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Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling

Polycomb repressive complex 2 (PRC2) controls maintenance and lineage determination of stem cells by suppressing genes that regulate cellular differentiation and tissue development. However, the role of PRC2 in lineage-committed somatic cells is mostly unknown. Here we show that Eed deficiency in ch...

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Publicat a:Nat Commun
Autors principals: Mirzamohammadi, Fatemeh, Papaioannou, Garyfallia, Inloes, Jennifer B., Rankin, Erinn B., Xie, Huafeng, Schipani, Ernestina, Orkin, Stuart H., Kobayashi, Tatsuya
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917962/
https://ncbi.nlm.nih.gov/pubmed/27329220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12047
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