Inhibition of Insulin Signaling in Endothelial Cells by Protein Kinase C-induced Phosphorylation of p85 Subunit of Phosphatidylinositol 3-Kinase (PI3K)

The regulation of endothelial function by insulin is consistently abnormal in insulin-resistant states and diabetes. Protein kinase C (PKC) activation has been reported to inhibit insulin signaling selectively in endothelial cells via the insulin receptor substrate/PI3K/Akt pathway to reduce the act...

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Detalhes bibliográficos
Main Authors: Maeno, Yasuhiro, Li, Qian, Park, Kyoungmin, Rask-Madsen, Christian, Gao, Benbo, Matsumoto, Motonobu, Liu, Yingjie, Wu, I-Hsien, White, Morris F., Feener, Edward P., King, George L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281670/
https://ncbi.nlm.nih.gov/pubmed/22158866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286591
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