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The Many Substrates of Presenilin/γ-Secretase
The Alzheimer’s disease (AD)-associated amyloid-β protein precursor (AβPP) is cleaved by α-, β-, and presenilin (PS)/γ-secretases through sequential regulated proteolysis. These proteolytic events control the generation of the pathogenic amyloid-β (Aβ) peptide, which excessively accumulates in the b...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3281584/ https://ncbi.nlm.nih.gov/pubmed/21335653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-101065 |
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