The S4–S5 Linker Acts as a Signal Integrator for hERG K(+) Channel Activation and Deactivation Gating

Human ether-à-go-go-related gene (hERG) K(+) channels have unusual gating kinetics. Characterised by slow activation/deactivation but rapid inactivation/recovery from inactivation, the unique gating kinetics underlie the central role hERG channels play in cardiac repolarisation. The slow activation...

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Bibliografiske detaljer
Main Authors: Ng, Chai Ann, Perry, Matthew D., Tan, Peter S., Hill, Adam P., Kuchel, Philip W., Vandenberg, Jamie I.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280985/
https://ncbi.nlm.nih.gov/pubmed/22359612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031640
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