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Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability
Translesion synthesis polymerases (TLS Pols) are required to tolerate DNA lesions that would otherwise cause replication arrest and cell death. Aberrant expression of these specialized Pols may be responsible for increased mutagenesis and loss of genome integrity in human cancers. The molecular even...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280556/ https://ncbi.nlm.nih.gov/pubmed/22157819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.457 |
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