An analog of BIX-01294 selectively inhibits a family of histone H3 lysine 9 Jumonji demethylases

BIX-01294 and its analogs were originally identified and subsequently designed as potent inhibitors against histone H3 lysine 9 (H3K9) methyltransferases G9a and G9a-like protein (GLP). Here we show BIX-01294 and its analog E67 can also inhibit H3K9 Jumonji demethylase KIAA1718 with half-maximal inh...

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Hlavní autoři: Upadhyay, Anup K., Rotili, Dante, Han, Ji Woong, Hu, Ruogu, Chang, Yanqi, Labella, Donatella, Zhang, Xing, Yoon, Young-sup, Mai, Antonello, Cheng, Xiaodong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280428/
https://ncbi.nlm.nih.gov/pubmed/22227394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.036
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