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Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases

Combinatorial readout of multiple covalent histone modifications is poorly understood. We provide insights into how an activating histone mark, in combination with linked repressive marks, is differentially ‘read’ by two related human demethylases, PHF8 and KIAA1718 (also known as JHDM1D). Both enzy...

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Autores principales: Horton, John R, Upadhyay, Anup K, Qi, Hank H, Zhang, Xing, Shi, Yang, Cheng, Xiaodong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849977/
https://ncbi.nlm.nih.gov/pubmed/20023638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1753
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