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Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases
Combinatorial readout of multiple covalent histone modifications is poorly understood. We provide insights into how an activating histone mark, in combination with linked repressive marks, is differentially ‘read’ by two related human demethylases, PHF8 and KIAA1718 (also known as JHDM1D). Both enzy...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849977/ https://ncbi.nlm.nih.gov/pubmed/20023638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1753 |
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